数据库名称：AIMaP
数据库简述：Atlas of Interactions between SARS-CoV-2 Macromolecules and host Proteins
所属国家/地区：China
数据库主要信息：Integrating the protein- and RNA-interactomes, we found that SARS-CoV-2 RNA and its N protein closely interacted with stress granules including 40 core factors, of which we specifically validated G3BP1, IGF2BP1, and MOV10 using RIP and Co-IP assays. Combining CRISPR screening results, we further identified 86 antiviral and 62 proviral factors and associated drugs. Using network diffusion, we found additional 44 interacting proteins including two proviral factors previously validated. Furthermore, we showed that this atlas could be applied to identify the complications associated with COVID-19.
建立年份：2023
联系信息：Contact information
University/Institution:
Wuhan University
Address:
College of Life Sciences, TaiKang Center for Life and Medical Sciences, RNA Institute, Wuhan University, Wuhan, China.
City:
Province/State:
Country/Region:
China
Contact name (PI/Team):
Yu Zhou
Contact email (PI/Helpdesk):
yu.zhou@whu.edu.cn
