数据库名称：CirRBP
数据库简述：CircRNA-Binding Proteins Site Prediction
所属国家/地区：China
数据库主要信息：Circular RNA (circRNA) can exert biological functions by interacting with RNA-binding protein (RBP), and some deep learning-based methods have been developed to predict RBP binding sites on circRNA. However, most of these methods identify circRNA-RBP binding sites are only based on single data resource and cannot provide exact binding sites, only providing the probability value of a sequence fragment. To solve these problems, we propose a binding sites localization algorithm that fuses binding sites from multiple databases, and further design a stacked generalization ensemble deep learning model named CirRBP to identify RBP binding sites on circRNA. The CirRBP is trained by combining the binding sites from multiple databases and makes predictions by weighted aggregating the predictions of each sub-model. The results show that the CirRBP outperforms any sub-model and existing online prediction model. For better access to our research results, we develop an open-source web application called CRWS (CircRNA-RBP Web Server).
建立年份：2022
联系信息：Contact information
University/Institution:
Shaanxi Normal University
Address:
School of Computer Science, Shaanxi Normal University, Xi’an 710119, China
City:
Province/State:
Country/Region:
China
Contact name (PI/Team):
Xiujuan Lei
Contact email (PI/Helpdesk):
xjlei@snnu.edu.cn
