数据库名称：DIPP
数据库简述：Disease-specific Imaging Probe Profiling
所属国家/地区：China
数据库主要信息：Molecular imaging probes can target abnormal gene expression patterns in patients and allow early diagnosis of disease. For selecting a suitable imaging probe, the current Molecular Imaging and Contrast Agent Database (MICAD) provides descriptive and qualitative information on imaging probe characteristics and properties. However, MICAD does not support linkage with the expression profiles of target genes. The proposed Disease-specific Imaging Probe Profiling (DIPP) database quantitatively archives and presents the gene expression profiles of targets across different diseases, anatomic regions, and subcellular locations, providing an objective reference for selecting imaging probes. The DIPP database was validated with a clinical positron emission tomography (PET) study on lung cancer and an in vitro study on neuroendocrine cancer. The retrieved records show that choline kinase beta and glucose transporters were positively and significantly associated with lung cancer among the targets of 11C-choline and [18F]fluoro-2-deoxy-2-d-glucose (FDG), respectively. Their significant overexpressions corresponded to the findings that the uptake rate of FDG increased with tumor size but that of 11C-choline remained constant. Validated with the in vitro study, the expression profiles of disease-associated targets can indicate the eligibility of patients for clinical trials of the treatment probe
建立年份：2014
联系信息：Contact information
University/Institution:
Chang Gung University
Address:
Department of Pharmacology, College of Medicine, Chang Gung University, Tao‐Yuan, Taiwan, R.O.C.
City:
Province/State:
Taiwan
Country/Region:
China
Contact name (PI/Team):
Benjamin Yat-Ming Yung
Contact email (PI/Helpdesk):
byung@mail.cgu.edu.tw
