数据库名称：GUTSY Atlas
数据库简述：An online atlas of human plasma metabolite signatures of gut microbiome composition
所属国家/地区：Sweden
数据库主要信息：Human gut microbiota produce a variety of molecules, some of which enter the bloodstream and impact health. Conversely, dietary or pharmacological compounds may affect the microbiota before entering the circulation. Characterization of these interactions is an important step towards understanding the effects of the gut microbiota on health. In this cross-sectional study, we used deep metagenomic sequencing and ultra-high-performance liquid chromatography linked to mass spectrometry for a detailed characterization of the gut microbiota and plasma metabolome, respectively, of 8583 participants invited at age 50 to 64 from the population-based Swedish CArdioPulmonary bioImage Study. Here, we find that the gut microbiota explain up to 58% of the variance of individual plasma metabolites and we present 997 associations between alpha diversity and plasma metabolites and 546,819 associations between specific gut metagenomic species and plasma metabolites in an online atlas ( https://gutsyatlas.serve.scilifelab.se/ ).
建立年份：2023
联系信息：Contact information
University/Institution:
Uppsala University
Address:
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. tove.fall@medsci.uu.se
City:
Province/State:
Country/Region:
Sweden
Contact name (PI/Team):
Koen Dekkers
Contact email (PI/Helpdesk):
koen.dekkers@medsci.uu.se
