数据库名称：HypDB
数据库简述：A functionally annotated web-based database of the proline hydroxylation proteome
所属国家/地区：United States
数据库主要信息：HypDB provides site-specific evidence of modification based on extensive LC-MS analysis and literature mining with 14,413 nonredundant Hyp sites on 5,165 human proteins including 3,383 Class I and 4,335 Class II sites. Annotation analysis revealed significant enrichment of Hyp on key functional domains and tissue-specific distribution of Hyp abundance across 26 types of human organs and fluids and 6 cell lines. The network connectivity analysis further revealed a critical role of Hyp in mediating protein-protein interactions. Moreover, the spectral library generated by HypDB enabled data-independent analysis (DIA) of clinical tissues and the identification of novel Hyp biomarkers in lung cancer and kidney cancer.
建立年份：2022
联系信息：Contact information
University/Institution:
University of Minnesota at Twin Cities
Address:
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota at Twin Cities, Minneapolis, Minnesota, United States of America.
City:
Province/State:
Country/Region:
United States
Contact name (PI/Team):
Yue Chen
Contact email (PI/Helpdesk):
yuechen@umn.edu
