数据库名称：Rhizoclip
数据库简述：
所属国家/地区：Belgium
数据库主要信息：Pseudomonas CLiPs are ubiquitous specialized metabolites, impacting the producer’s lifestyle and interactions with the (a)biotic environment. Consequently, they generate interest for agricultural and clinical applications. Establishing structure-activity relationships as a premise to their development is hindered because full structural characterization including stereochemical information requires labor-intensive analyses, without guarantee for success. Moreover, increasing use of superficial comparison with previously characterized CLiPs introduces or propagates erroneous attributions, clouding further scientific progress. We provide a generally applicable characterization methodology based on matching NMR spectral fingerprints of newly isolated CLiPs to natural and synthetic reference compounds with (un)known stereochemistry. In addition, NMR fingerprinting is shown to provide a suitable basis for structural dereplication. A publicly available reference compound repository promises to facilitate participation of the lipopeptide research community in structural assessment and dereplication of newly isolated CLiPs, which should also support further developments in genome mining for novel CLiPs.
建立年份：2022
联系信息：Contact information
University/Institution:
Ghent University
Address:
NMR and Structure Analysis Unit, Ghent Universitygrid.5342.0, Department of Organic and Macromolecular Chemistry, Ghent, Belgium.
City:
Province/State:
Country/Region:
Belgium
Contact name (PI/Team):
José C Martins
Contact email (PI/Helpdesk):
jose.martins@ugent.be
