数据库名称：TBEVHostDB
数据库简述：Tick-borne encephalitis virus host database
所属国家/地区：Russian Federation
数据库主要信息：TBEVHostDB — a catalog of human genes that are probably involved in response to TBEV infection. It was created based on manual review and curation of scientific publications. If the publication described a non-human mammalian gene/protein, the homologous human gene was found and included into the catalog. At present a catalog contains 140 human genes. Genes are classified into functional categories (datasets) according to five types of evidence: (1) genes encoding proteins that had direct physical interactions with TBE viral particle, TBEV proteins or RNA.; (2) genes encoding mRNAs (or proteins) that were up- or down-regulated in response to TBEV infection ; (3) allelic variants in these genes are associated with susceptibility or resistance to TBEV infection; (4) these proteins were required for inhibitory effect of other proteins against TBEV or attenuated its antiviral activity; (5) knockout of these genes in mice increased mortality rates or affected the other clinical manifestations of the disease.
建立年份：2017
联系信息：Contact information
University/Institution:
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Address:
The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia.
City:
Novosibirsk
Province/State:
Country/Region:
Russian Federation
Contact name (PI/Team):
Elena V. Ignatieva
Contact email (PI/Helpdesk):
eignat@bionet.nsc.ru
