数据库名称：TMECircDB
数据库简述：Tumor MicroEnvironment specific CircRNA DataBase
所属国家/地区：United States
数据库主要信息：To address this, we performed total RNA sequencing (RNA-seq) on 30 matched normal, primary and metastatic samples from 14 mCRC patients. Additionally, five CRC cell lines were sequenced to construct a circRNA catalog in CRC. We detected 47 869 circRNAs, with 51% previously unannotated in CRC and 14% novel candidates when compared to existing circRNA databases. We identified 362 circRNAs differentially expressed in primary and/or metastatic tissues, termed circular RNAs associated with metastasis (CRAMS). We performed cell-type deconvolution using published single-cell RNA-seq datasets and applied a non-negative least squares statistical model to estimate cell-type specific circRNA expression. This predicted 667 circRNAs as exclusively expressed in a single cell type.
建立年份：2023
联系信息：Contact information
University/Institution:
Washington University in St. Louis
Address:
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63108, USA.
City:
Province/State:
Country/Region:
United States
Contact name (PI/Team):
Christopher A Maher
Contact email (PI/Helpdesk):
christophermaher@wustl.edu
