数据库名称：TRIPBASE
数据库简述：a database for identifying the human genomic DNA and lncRNA triplexes
所属国家/地区：China
数据库主要信息：Long-non-coding RNAs (lncRNAs) are defined as RNA sequences which are >200 nt with no coding capacity. These lncRNAs participate in various biological mechanisms, and are widely abundant in a diversity of species. There is well-documented evidence that lncRNAs can interact with genomic DNAs by forming triple helices (triplexes). Previously, several computational methods have been designed based on the Hoogsteen base-pair rule to find theoretical RNA-DNA:DNA triplexes. While powerful, these methods suffer from a high false-positive rate between the predicted triplexes and the biological experiments. To address this issue, we first collected the experimental data of genomic RNA-DNA triplexes from antisense oligonucleotide (ASO)-mediated capture assays and used Triplexator, the most widely used tool for lncRNA-DNA interaction, to reveal the intrinsic information on true triplex binding potential.
建立年份：2023
联系信息：Contact information
University/Institution:
Institute of Information Science, Academia Sinica
Address:
Institute of Information Science, Academia Sinica, Taipei, 11529, Taiwan.
City:
Province/State:
Country/Region:
China
Contact name (PI/Team):
Huai-Kuang Tsai
Contact email (PI/Helpdesk):
hktsai@iis.sinicaedu.tw
