基因名称：ABCB1 （ATP binding cassette subfamily B member 1）
别名： ABC20,CD243,CLCS,GP170,MDR1,P-GP,PGY1
基因ID：5243
Chromosome(GRCh37) ：7 Start: 87133175 End: 87342611 Strand: -1
信号通路： 基因组不稳定
靶向药：
化疗药：卡铂 顺铂 紫杉醇
简介：由该基因编码的膜相关蛋白是ATP结合盒（ABC）转运蛋白超家族的成员。ABC蛋白通过细胞外膜和细胞内膜转运各种分子。ABC基因分为7个不同的亚家族（abc1，mdr/tap，mrp，ald，oabp，gcn20，white）。这种蛋白是MDR/TAP亚家族的成员。MDR/TAP亚家族成员参与多药耐药。该基因编码的蛋白质是一种具有广泛底物特异性的外源性化合物的ATP依赖性药物外排泵。它负责减少多药耐药细胞中的药物积累，并经常介导抗肿瘤药物的发展。这种蛋白也作为血脑屏障的转运蛋白发挥作用。The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
ABCB1突变与药物：
I1145I
药物：
卡铂 顺铂 疾病：
乳腺癌
非小细胞肺癌
S893T
药物：
紫杉醇 疾病：
卵巢癌
S893A/T
药物：
Ziv-阿柏西普
疾病：
乳腺癌
EXPRESSION
药物：
紫杉醇 疾病：
非小细胞肺癌
