基因名称：ABCC4 （ATP binding cassette subfamily C member 4）
别名： MRP4,MOATB,MOAT-B
基因ID：10257
Chromosome(GRCh37) ：13 Start: 95672083 End: 95953705 Strand:
信号通路： 能量代谢
靶向药：
化疗药：
简介：该基因编码的蛋白质是atp结合盒（abc）转运蛋白超家族的成员。abc蛋白通过细胞外和细胞内的膜运输各种分子。abc基因分为七个不同的亚家族（abc1，mdr/tap，mrp，ald，oabp，gcn20，white）。该蛋白是mrp亚家族的一员，参与多药耐药。这一家族成员在细胞解毒过程中扮演着泵的角色，为其底物，有机阴离子。它也可能在前列腺素介导的cAMP信号传导中起作用。该基因的选择性剪接导致多个转录变体。[由RefSeq提供，2014年9月]The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
ABCC4突变与药物：
