基因名称：AFDN （afadin, adherens junction formation factor）
别名： AF6,MLLT4,MLL-AF6,l-afadin
基因ID：4301
Chromosome(GRCh37) ：6 Start: 168227602 End: 168372703 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码一个多域蛋白，参与胚胎发育过程中细胞连接的信号和组织该基因与t（6；11）（q27；q23）易位的急性髓系白血病（americ myeloid leukemia，all-1）基因融合。另外，编码不同亚型的剪接转录变体已经被描述用于该基因，然而，并不是所有的都已经被完全描述出来了。[由RefSeq提供，2011年5月]This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
AFDN突变与药物：
