基因名称:AFF4 (AF4/FMR2 family member 4)
别名: MCEF,CHOPS,AF5Q31
基因ID:27125
Chromosome(GRCh37) :5 Start: 132211071 End: 132299354 Strand:
信号通路:
靶向药:
化疗药:
简介:该基因编码的蛋白属于白血病相关转录因子AF4家族它是正转录延长因子b(p-tefb)复合物的组成部分。在患有ins(5;11)(q31;q31q23)的婴儿急性淋巴细胞白血病中发现了一个染色体易位,涉及该基因和11号染色体上的mll基因。[由RefSeq提供,2011年10月]The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23). [provided by RefSeq, Oct 2011]
AFF4突变与药物: