基因名称：AKT3 （AKT serine/threonine kinase 3）
别名： MPPH,MPPH2,PKB-GAMMA,PKBG,PRKBG,RAC-PK-gamma,RAC-gamma,STK-2
基因ID：10000
Chromosome(GRCh37) ：1 Start: 243651535 End: 244014381 Strand: -1
信号通路： 细胞增殖
免疫相关
炎症相关
血管生成
凋亡抑制
能量代谢
靶向药： AKT3 Inhibitor GSK690693
MK-2206 2HCl
维莫非尼,威罗菲尼
化疗药：
简介：这个基因编码的蛋白质是AKT的一个成员，也被称为pkb，丝氨酸/苏氨酸蛋白激酶家族。Akt激酶是已知的细胞信号调节器，对胰岛素和生长因子作出反应。参与多种生物学过程，包括细胞增殖、分化、凋亡、肿瘤发生以及糖原合成和葡萄糖摄取。这种激酶被血小板衍生生长因子（pdgf）、胰岛素和胰岛素样生长因子1（igf1）刺激。另外，还描述了编码不同亚型的剪接转录变体。The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
AKT3突变与药物：
OVEREXPRESSION
药物：
AKT3 Inhibitor GSK690693
MK-2206 2HCl
维莫非尼,威罗菲尼
疾病：
乳腺癌
黑色素瘤
三受体阴性乳腺癌
E17K
药物：
维莫非尼,威罗菲尼
疾病：
黑色素瘤
