基因名称：APOBEC3B （apolipoprotein B mRNA editing enzyme catalytic subunit 3B）
别名： A3B,ARP4,ARCD3,PHRBNL,APOBEC1L,bK150C2.2,DJ742C19.2
基因ID：9582
Chromosome(GRCh37) ：22 Start: 39378352 End: 39388784 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因属于胞苷脱氨酶基因家族。它是在22号染色体上发现的7个相关基因或假基因之一，被认为是基因复制的结果。该簇的成员编码的蛋白质在结构和功能上与编辑cytidine脱氨酶APOBEC1的C到U RNA相关人们认为这些蛋白质可能是RNA编辑酶，在生长或细胞周期控制中起作用一个杂合基因是由该基因ApBEC3B和相邻基因ApBEC3A缺失约29.5 kb的序列导致的，缺失位点位于两个基因内，因此缺失等位基因被预测为APOBEC3A的启动子和编码区。但是apobec3b的3’utr。已经发现了两个编码不同亚型的转录变体。[由RefSeq提供，2012年7月]This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3′ UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
APOBEC3B突变与药物：
