基因名称：ARFGEF2 （ADP ribosylation factor guanine nucleotide exchange factor 2）
别名： BIG2,PVNH2,dJ1164I10.1
基因ID：10564
Chromosome(GRCh37) ：20 Start: 47538250 End: 47653230 Strand:
信号通路：
靶向药：
化疗药：
简介：adp-核糖化因子（arfs）在细胞内囊泡转运中起重要作用。该基因编码的蛋白通过加速GTP替代结合的GDP参与ARFs的激活，并参与高尔基体的转运它含有一个Sec7结构域，可能与它的鸟嘌呤核苷酸交换活性和布雷菲尔德a抑制有关[由RefSeq提供，2008年7月]ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
ARFGEF2突变与药物：
