ATP11B靶向药基因

基因名称:ATP11B  (ATPase phospholipid transporting 11B (putative))

别名: ATPIF,ATPIR
基因ID:23200
Chromosome(GRCh37) :3 Start: 182511291 End: 182639423 Strand:
信号通路:
靶向药:
化疗药:

简介:P型atp酶,如atpp11b,在其中间状态被磷酸化,并推动离子在膜上的上坡转运已鉴定出P型atp酶的几个亚家族一个亚科运输重金属离子,如cu(2+)、cd(2+)。另一个亚科运输非重金属离子,如H+、Na+、K+、或Ca+。第三个亚科运输两栖动物,如磷脂酰丝氨酸。P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]
ATP11B突变与药物:

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