BBC3靶向药基因

基因名称:BBC3  (BCL2 binding component 3)

别名: JFY1,PUMA,JFY-1
基因ID:27113
Chromosome(GRCh37) :19 Start: 47724079 End: 47736023 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因编码bcl-2蛋白家族的一个成员。这个家族成员属于BH3唯一的促凋亡亚类。该蛋白与直接激活蛋白协同作用,诱导线粒体外膜通透性和凋亡。它能与抗凋亡的bcl-2家族成员结合,诱导线粒体功能障碍和caspase活化。由于其促凋亡的作用,该基因是肿瘤治疗和组织损伤的潜在药物靶点。选择性剪接导致多个转录变体。[由RefSeq提供,2011年12月]This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
BBC3突变与药物:

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