BCL3靶向药基因

基因名称:BCL3  (BCL3 transcription coactivator)

别名: BCL4,D19S37
基因ID:602
Chromosome(GRCh37) :19 Start: 45246070 End: 45263301 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因是原癌基因候选基因在某些B细胞白血病病例中,它通过转移到免疫球蛋白α位点而被识别。该基因编码的蛋白质含有七个锚蛋白重复序列,它们与i-kappa b蛋白最为密切相关。该蛋白通过与nf-kappa b同源二聚体的结合起转录辅激活作用。NF-kappa B可以诱导该基因的表达,它构成了控制p50-NF-kappab核居住地的自我调节回路的一部分This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
BCL3突变与药物:

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