基因名称：BCL6 （BCL6 transcription repressor）
别名： BCL5,LAZ3,BCL6A,ZNF51,ZBTB27
基因ID：604
Chromosome(GRCh37) ：3 Start: 187439165 End: 187463513 Strand:
信号通路： 免疫相关
基因组不稳定
肿瘤干细胞
靶向药：
化疗药：
简介：该基因编码的蛋白是锌指转录因子，含有一个n端poz结构域。该蛋白作为一种序列特异性的转录抑制因子，已被证明调节b细胞stat依赖性il-4应答的转录。这种蛋白质可以与多种poz蛋白相互作用，poz蛋白具有转录辅压作用。该基因在弥漫性大细胞淋巴瘤（dlcl）中常发生易位和过度突变，可能参与dlcl的发病机制。另外，已经发现了编码不同蛋白质亚型的剪接转录变体。[由RefSeq提供，2015年8月]The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
BCL6突变与药物：
