基因名称：BIRC2 （baculoviral IAP repeat containing 2）
别名： API1,MIHB,HIAP2,RNF48,cIAP1,Hiap-2,c-IAP1
基因ID：329
Chromosome(GRCh37) ：11 Start: 102217913 End: 102249401 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码的蛋白是一个蛋白家族的成员，通过与肿瘤坏死因子受体相关因子traf1和traf2结合抑制细胞凋亡，可能通过干扰类冰蛋白酶的激活。这种编码蛋白抑制由血清剥夺和甲萘醌（一种有效的自由基诱导剂）诱导的细胞凋亡另一种编码不同的异构体的剪接转录变体已被发现用于该基因。[由RefSeq提供，2012年1月]The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
BIRC2突变与药物：
