基因名称：BIRC7 （baculoviral IAP repeat containing 7）
别名： KIAP,LIVIN,ML-IAP,MLIAP,RNF50
基因ID：79444
Chromosome(GRCh37) ：20 Start: 61867235 End: 61871859 Strand: 1
信号通路：
靶向药：
化疗药：顺铂
简介：该基因编码凋亡抑制蛋白（IAP）家族的一个成员，包含杆状病毒IAP重复序列（BIR）的单一拷贝和环状锌指结构域。BIR结构域对抑制活性至关重要，与半胱天冬酶相互作用，而环指结构域有时增强抗凋亡活性，但不单独抑制凋亡。编码蛋白水平升高可能与癌症进展有关，并在化疗敏感性中发挥作用。选择性剪接导致多个转录变体This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants
BIRC7突变与药物：
AMPLIFICATION
药物：
顺铂 疾病：
结肠癌
