基因名称:BLK (BLK proto-oncogene, Src family tyrosine kinase)
别名: MODY11
基因ID:640
Chromosome(GRCh37) :8 Start: 11351521 End: 11422108 Strand:
信号通路:
靶向药:
化疗药:
简介:该基因编码src原癌基因家族的一个非受体酪氨酸激酶,典型地参与细胞增殖和分化该蛋白在b细胞受体信号传导和b细胞发育中起作用。该蛋白还刺激胰岛素的合成和分泌,对葡萄糖作出反应,并增强一些胰腺β细胞转录因子的表达[由RefSeq提供,2010年8月]This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]
BLK突变与药物: