基因名称:BRD7 (bromodomain containing 7)
别名: BP75,NAG4,CELTIX1
基因ID:29117
Chromosome(GRCh37) :16 Start: 50352929 End: 50402845 Strand:
信号通路:
靶向药:
化疗药:
简介:这个基因编码一种蛋白质,它是一种含有溴多胺的蛋白质家族的成员。该基因的产物被认为是swi/snf染色质重塑复合物的一种组成成分,是一种与p53相互作用的蛋白质,是p53依赖癌基因诱导的阻止肿瘤生长的衰老所必需的。假基因在2、3、6、13和14号染色体上都有描述。选择性剪接导致多个转录变体。[由RefSeq提供,2010年7月]This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
BRD7突变与药物: