基因名称：BUB1B （BUB1 mitotic checkpoint serine/threonine kinase B）
别名： MVA1,SSK1,BUBR1,Bub1A,MAD3L,hBUBR1,BUB1beta
基因ID：701
Chromosome(GRCh37) ：15 Start: 40453210 End: 40513337 Strand:
信号通路：
靶向药：
化疗药：
简介：这个基因编码一个参与纺锤体检查点功能的激酶。该蛋白已定位于动粒，并在抑制后期促进复合物/环小体（apc/c）中发挥作用，延缓后期的发生，确保染色体的正确分离。纺锤体检查点功能受损已在多种癌症中发现。[由RefSeq提供，2008年7月]This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]
BUB1B突变与药物：
