CARD11靶向药基因

基因名称:CARD11  (caspase recruitment domain family member 11)

别名: PPBL,BENTA,BIMP3,IMD11,CARMA1,IMD11A
基因ID:84433
Chromosome(GRCh37) :7 Start: 2945709 End: 3083579 Strand:
信号通路: 免疫相关
靶向药:
化疗药:

简介:该基因编码的蛋白属于膜相关鸟苷酸激酶(maguk)家族,是一类在质膜特定区域组装多蛋白复合物的分子支架蛋白。该蛋白也是card蛋白家族的一员,card蛋白家族的定义是携带一个特征性的caspase相关募集域(card)。该蛋白具有与card14蛋白相似的结构域。这两种蛋白的card结构域都被证明与bcl10有特异性的相互作用,bcl10是一种已知的对细胞凋亡和nf-kappab活化起积极调节作用的蛋白。当在细胞中表达时,该蛋白激活nf-kappab并诱导bcl10磷酸化。[由RefSeq提供,2008年7月]The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]
CARD11突变与药物:

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