基因名称：CBFA2T3 （CBFA2/RUNX1 translocation partner 3）
别名： ETO2,MTG16,MTGR2,RUNX1T3,ZMYND4
基因ID：863
Chromosome(GRCh37) ：16 Start: 88941266 End: 89043612 Strand: -1
信号通路：
靶向药：
化疗药：
简介：该基因编码髓系易位基因家族的一个成员，该家族与DNA结合转录因子相互作用，并招募一系列共加压因子以促进转录抑制。T（16；21）（q24；q22）易位是急性髓性白血病较少见的核型异常之一。易位产生一个由RUNT相关转录因子1基因的5’-区与该基因的3’-区融合构成的嵌合基因。这个基因也是一个假定的乳腺肿瘤抑制基因。选择性剪接导致转录变异。This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5′-region of the runt-related transcription factor 1 gene fused to the 3′-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
CBFA2T3突变与药物：
CBFA2T3-GLIS2 fusion
药物：
Ziv-阿柏西普
疾病：
急性髓性白血病
