CCNE1靶向药基因BMS-387032 (SNS-032)　MK-7965　 氟维司群　 MK-2206 2HCl　 哌柏西利/帕博西尼/帕博西林

基因名称：CCNE1  （cyclin E1）

别名： CCNE,pCCNE1
基因ID：898
Chromosome(GRCh37) ：19　Start:　30302805　End:　30315215　Strand:　1
信号通路： 细胞增殖　
细胞周期　
基因组不稳定
靶向药： BMS-387032 (SNS-032)　MK-7965　
氟维司群　
MK-2206 2HCl　
哌柏西利/帕博西尼/帕博西林
化疗药：

简介：该基因编码的蛋白质属于高度保守的细胞周期蛋白家族，其成员在细胞周期内具有显著的蛋白质丰度周期性。细胞周期蛋白起着调节CDK激酶的作用。不同的细胞周期蛋白表现出不同的表达和降解模式，这有助于每个有丝分裂事件的时间协调。该细胞周期蛋白与CDK2形成复合物并作为其调节亚单位发挥作用，其活性是细胞周期G1/S转换所必需的。这种蛋白在G1-S相边界处积累，并随着细胞进入S相而降解。这种基因在许多肿瘤中过度表达，导致染色体不稳定，从而可能有助于肿瘤的发生。研究发现，这种蛋白与NPAT蛋白的磷酸化（与ATM位点对应的核蛋白）有关并参与其中，NPAT蛋白参与细胞周期调节组蛋白基因的表达，并在无prb的情况下在促进细胞周期进展中起到关键作用。The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
CCNE1突变与药物：
OVEREXPRESSION
药物：
BMS-387032 (SNS-032) 疾病：
乳腺癌
胃腺鳞癌 卵巢癌

AMPLIFICATION
药物：
MK-7965　
MK-2206 2HCl　
Palbociclib (PD0332991) 疾病：
雌激素受体阳性乳腺癌 卵巢癌
卵巢浆液性囊腺癌
ｍRNA expression low
药物：
氟维司群　
哌柏西利/帕博西尼/帕博西林　
疾病：
乳腺癌