基因名称：CD70 （CD70 molecule）
别名： CD27L,LPFS3,CD27-L,CD27LG,TNFSF7,TNLG8A
基因ID：970
Chromosome(GRCh37) ：19 Start: 6582969 End: 6591163 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码的蛋白是一种细胞因子，属于肿瘤坏死因子（TNF）配体家族。这种细胞因子是TNFRSF27/CD27的配体。它是活化的T淋巴细胞和B淋巴细胞的表面抗原，而不是静止的T淋巴细胞和B淋巴细胞的表面抗原。它诱导共刺激t细胞的增殖，促进溶细胞t细胞的产生，并有助于t细胞的活化。该细胞因子还被报道在调节B细胞活化、自然杀伤细胞的细胞毒性功能和免疫球蛋白合成中发挥作用。[由RefSeq提供，2008年7月]The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
CD70突变与药物：
