基因名称：CDC73 （cell division cycle 73）
别名： HYX,FIHP,HPTJT,HRPT1,HRPT2,C1orf28
基因ID：79577
Chromosome(GRCh37) ：1 Start: 193091088 End: 193223945 Strand:
信号通路： 细胞周期
肿瘤干细胞
靶向药：
化疗药：
简介：该基因编码一种参与转录和转录后控制途径的肿瘤抑制因子。该蛋白是paf蛋白复合物的一个组成部分，它与rna聚合酶ii亚单位polr2a和组蛋白甲基转移酶复合物相关。这种蛋白质似乎有助于3’mrna处理因子与主动转录的染色质的关联。该基因突变与甲状旁腺功能亢进症、颌骨肿瘤综合征、家族性孤立性甲状旁腺功能亢进症和甲状旁腺癌有关。[由RefSeq提供，2009年7月]This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3′ mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]
CDC73突变与药物：
