CDH20靶向药基因

基因名称:CDH20  (cadherin 20)

别名: Cdh7,CDH7L3
基因ID:28316
Chromosome(GRCh37) :18 Start: 59000815 End: 59237123 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因是来自钙黏蛋白超家族的ii型经典型钙黏蛋白,是位于18号染色体簇中的三个类钙黏蛋白7基因之一。编码的膜蛋白是一种钙依赖性细胞粘附糖蛋白,由5个细胞外钙黏蛋白重复序列、一个跨膜区和一个高度保守的胞质尾组成。II型(非典型)钙粘蛋白的定义是基于其缺乏一个特定于I型钙粘蛋白的HAV细胞粘附识别序列。由于细胞内粘附障碍是肿瘤细胞侵袭和转移的先决条件,钙粘蛋白被认为是肿瘤抑制基因的主要候选基因。[由RefSeq提供,2008年7月]This gene is a type II classical cadherin from the cadherin superfamily and one of three cadherin 7-like genes located in a cluster on chromosome 18. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Since disturbance of intracellular adhesion is a prerequisite for invasion and metastasis of tumor cells, cadherins are considered prime candidates for tumor suppressor genes. [provided by RefSeq, Jul 2008]
CDH20突变与药物:

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