基因名称：CDK1 （cyclin dependent kinase 1）
别名： CDC2,CDC28A,P34CDC2
基因ID：983
Chromosome(GRCh37) ：10 Start: 62538089 End: 62554610 Strand:
信号通路：
靶向药：
化疗药：
简介：这个基因编码的蛋白质是ser/thr蛋白激酶家族的成员。该蛋白是高度保守的蛋白激酶复合物m相促进因子（mpf）的催化亚单位，对真核细胞周期g1/s和g2/m相转变至关重要。有丝分裂细胞周期素与此蛋白稳定结合，并作为调节亚单位发挥作用。这种蛋白的激酶活性是由细胞周期中细胞周期蛋白的积累和破坏所控制的。该蛋白的磷酸化和去磷酸化在细胞周期调控中也起着重要的调控作用。另外，已经发现该基因编码不同亚型的剪接转录变体。[由RefSeq提供，2009年3月]The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
CDK1突变与药物：
