基因名称：CDK8 （cyclin dependent kinase 8）
别名： K35
基因ID：1024
Chromosome(GRCh37) ：13 Start: 26828262 End: 26979375 Strand:
信号通路： 细胞周期
能量代谢
肿瘤干细胞
靶向药：
化疗药：
简介：该基因编码细胞周期蛋白依赖性蛋白激酶（cdk）家族的一个成员。cdk家族成员是细胞周期进展的重要调节者。这种激酶及其调节亚单位，细胞周期蛋白c，是介体转录调节复合物的组成部分，参与转录激活和rna聚合酶ii最大亚单位羧基末端结构域磷酸化的抑制。该激酶通过靶向一般转录起始因子iih的细胞周期蛋白依赖性激酶7亚单位来调节转录，从而在介体复合体和基础转录机制之间提供一个连接。已鉴定出该基因的多个假基因。选择性剪接导致多个转录变体。[由RefSeq提供，2016年10月]This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
CDK8突变与药物：
