CHD3靶向药基因

基因名称:CHD3  (chromodomain helicase DNA binding protein 3)

别名: ZFH,Mi-2a,SNIBCPS,Mi2-ALPHA
基因ID:1107
Chromosome(GRCh37) :17 Start: 7788096 End: 7816075 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因编码chd蛋白家族的一个成员,其特征是存在染色质组织修饰区和snf2相关的螺旋酶/atpase结构域。该蛋白是组蛋白去乙酰化酶复合物(mi-2/nurd复合物)的组成部分之一,该复合物通过去乙酰化组蛋白参与染色质的重塑。染色质重塑是包括转录在内的许多过程中必不可少的。抗这种蛋白的自身抗体存在于皮肌炎患者中。已经描述了编码不同亚型的三个选择性剪接转录本。[由RefSeq提供,2008年7月]This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
CHD3突变与药物:

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