基因名称:CHUK (component of inhibitor of nuclear factor kappa B kinase complex)
别名: IKK1,IKKA,IKBKA,TCF16,NFKBIKA,IKK-alpha
基因ID:1147
Chromosome(GRCh37) :10 Start: 101948123 End: 101989367 Strand:
信号通路:
靶向药:
化疗药:
简介:这个基因编码丝氨酸/苏氨酸蛋白激酶家族的一个成员。编码蛋白是一种细胞因子激活蛋白复合物的组成部分,它是必需转录因子nf-kappa-b复合物的抑制剂,磷酸化位点通过增溶途径触发抑制剂的降解,从而激活转录因子。[由RefSeq提供,2008年7月]This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
CHUK突变与药物: