基因名称：CLK2 （CDC like kinase 2）
别名：
基因ID：1196
Chromosome(GRCh37) ：1 Start: 155232659 End: 155243305 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码一种双特异性蛋白激酶，磷酸化丝氨酸/苏氨酸和酪氨酸底物。该蛋白的活性调节剪接体复合体中富含丝氨酸和精氨酸（SR）的蛋白质，从而影响选择性转录剪接。该位点与19号染色体上的pafah1b3（血小板活化因子乙酰水解酶1b，催化亚单位3（29kDa））基因之间的染色体易位已经被证实，从而产生了融合蛋白。注意，该基因与telo2基因（geneid:9894）不同，后者共享clk2别名，但编码一种参与端粒长度调节的蛋白质。在7号染色体上有一个假基因。选择性剪接导致多个转录变体[由RefSeq提供，2014年6月]This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
CLK2突变与药物：
