基因名称：CYP1A2 （cytochrome P450 family 1 subfamily A member 2）
别名： CP12,CYPIA2,P3-450,P450(PA)
基因ID：1544
Chromosome(GRCh37) ：15 Start: 75041184 End: 75048941 Strand:
信号通路： 能量代谢
靶向药：
化疗药：
简介：该基因编码细胞色素p450酶超家族的一个成员。细胞色素p450蛋白是一种单加氧酶，催化药物代谢和胆固醇、类固醇等脂类的合成。该基因编码的蛋白质定位于内质网，其表达由一些多环芳烃（pahs）诱导，其中一些存在于香烟烟雾中。该酶的内源底物尚不清楚，但它能将一些多环芳烃代谢为致癌中间体。这种酶的其他异种底物包括咖啡因、黄曲霉毒素B1和对乙酰氨基酚。这个基因的转录本包含四个alu序列，在3’未翻译区域有直接重复。[由RefSeq提供，2008年7月]This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme’s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3′ untranslated region. [provided by RefSeq, Jul 2008]
CYP1A2突变与药物：
