基因名称：CYP2C8 （cytochrome P450 family 2 subfamily C member 8）
别名： CPC8,CYPIIC8,CYP2C8DM,MP-12/MP-20
基因ID：1558
Chromosome(GRCh37) ：10 Start: 96796529 End: 96829255 Strand:
信号通路： 能量代谢
靶向药：
化疗药：
简介：该基因编码细胞色素p450酶超家族的一个成员。细胞色素p450蛋白是一种单加氧酶，催化药物代谢和胆固醇、类固醇等脂类的合成。该蛋白定位于内质网，由苯巴比妥诱导表达。众所周知，这种酶能代谢多种外源性物质，包括抗惊厥药苯妥英、苯并（a）芘、7-乙氧基香豆素和抗癌药紫杉醇。该基因位于染色体10q24上的细胞色素p450基因簇内。已经发现了一些编码一些不同亚型的转录变体。[由RefSeq提供，2010年11月]This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
CYP2C8突变与药物：
