CYP4B1靶向药基因

基因名称:CYP4B1  (cytochrome P450 family 4 subfamily B member 1)

别名: CYPIVB1,P-450HP
基因ID:1580
Chromosome(GRCh37) :1 Start: 47264670 End: 47285021 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因编码细胞色素P450酶超家族的一个成员细胞色素p450蛋白是一种单加氧酶,催化药物代谢和胆固醇、类固醇等脂类的合成。这种蛋白质定位于内质网在啮齿类动物中,同源蛋白被证明能代谢某些致癌物质,但人类蛋白的特殊功能尚未确定已发现该基因的多个转录变体。[由RefSeq提供,2016年1月]This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
CYP4B1突变与药物:

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