DNAJB1靶向药基因

基因名称：DNAJB1  （DnaJ heat shock protein family (Hsp40) member B1）

别名： Hdj1,Sis1,HSPF1,Hsp40,RSPH16B
基因ID：3337
Chromosome(GRCh37) ：19　Start:　14625581　End:　14640087　Strand:
信号通路：
靶向药：
化疗药：

简介：该基因编码dnaj或hsp40（热休克蛋白40kd）家族的一个成员。dnaj家族成员具有高度保守的氨基酸结构，称为j域，是两类主要的分子伴侣之一，参与多种细胞活动，如蛋白质折叠和寡聚蛋白复合物组装。编码蛋白是一种分子伴侣，它刺激hsp70热休克蛋白的atp酶活性，以促进蛋白折叠和防止错误折叠的蛋白聚集。选择性剪接导致多个转录变体。[由RefSeq提供，2015年9月]This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the ‘J-domain’ and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
DNAJB1突变与药物：