基因名称:DROSHA (drosha ribonuclease III)
别名: ETOHI2,HSA242976,RANSE3L,RN3,RNASE3L,RNASEN
基因ID:29102
Chromosome(GRCh37) :5 Start: 31400604 End: 31532303 Strand: -1
信号通路:
靶向药:
化疗药:
简介:双链(ds)RNA特异性内核糖核酸酶III超家族成员参与真核细胞和原核细胞的多种RNA成熟和衰变途径(Fortin等人,2002[PubMed 12191433])。RNase III Drosha是核心核酸酶,执行细胞核中microRNA(microRNA)处理的起始步骤(Lee等人,2003[PubMed 14508493])。Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).
DROSHA突变与药物:
563053
药物:
Ziv-阿柏西普
疾病:
癌症
E518K
药物:
Ziv-阿柏西普
疾病:
肾威尔姆斯肿瘤