基因名称：ECSCR （endothelial cell surface expressed chemotaxis and apoptosis regulator）
别名： ARIA,ECSM2
基因ID：641700
Chromosome(GRCh37) ：5 Start: 138784245 End: 138842328 Strand: -1
信号通路：
靶向药： Antiangiogenic Therapy
化疗药：
简介：该基因编码的蛋白质主要存在于内皮细胞和血管中，参与细胞形态变化和表皮生长因子诱导的细胞迁移。能增强血管内皮生长因子受体-2/激酶插入结构域受体的活化，并促进内化激酶插入结构域受体的蛋白水解。该基因可能在血管生成相关疾病中发挥作用。选择性剪接导致多个转录变体。The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants.
ECSCR突变与药物：
EXPRESSION
药物：
Antiangiogenic Therapy 疾病：
癌症
