基因名称：EIF4E （eukaryotic translation initiation factor 4E）
别名： CBP,EIF4F,AUTS19,EIF4E1,eIF-4E,EIF4EL1
基因ID：1977
Chromosome(GRCh37) ：4 Start: 99799607 End: 99851786 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因编码的蛋白质是真核翻译起始因子4f复合物的一个组成部分，该复合物识别信使rna 5’端的7-甲基鸟苷cap结构。编码的蛋白质通过将核糖体招募到5′-cap结构来帮助翻译起始。该蛋白与4f复合物的结合是翻译起始的限速步骤。该基因作为原癌基因，其表达和激活与转化和肿瘤发生有关。在其他染色体上发现了该基因的一些假基因。选择性剪接导致多个转录变体。[由RefSeq提供，2015年9月]The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5′ end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5′-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
EIF4E突变与药物：
