基因名称：EPCAM （epithelial cell adhesion molecule）
别名： DIAR5,EGP-2,EGP314,EGP40,ESA,HNPCC8,KS1/4,KSA,M4S1,MIC18,MK-1,TACSTD1,TROP1
基因ID：4072
Chromosome(GRCh37) ：2 Start: 47572297 End: 47614740 Strand: 1
信号通路： 侵袭和转移
遗传相关
靶向药：
化疗药：
简介：该基因编码癌相关抗原，是一个家族的成员，至少包含两种I型膜蛋白。这种抗原在大多数正常上皮细胞和胃肠道癌上表达，并作为一种同型钙依赖性细胞粘附分子发挥作用。该抗原正被用作人类癌免疫治疗的靶点。该基因突变导致先天性丛生性肠病。This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
EPCAM突变与药物：
3′ EXON DELETION
药物：
Ziv-阿柏西普
疾病：
林奇综合征
