EPHA1靶向药基因

基因名称:EPHA1  (EPH receptor A1)

别名: EPH,EPHT,EPHT1
基因ID:2041
Chromosome(GRCh37) :7 Start: 143088205 End: 143105985 Strand:
信号通路:
靶向药:
化疗药:

简介:该基因属于酪氨酸蛋白激酶家族的肾上腺素受体亚家族eph和eph相关受体参与了发育事件的调节,特别是在神经系统中。eph亚家族的受体通常有一个单一的激酶结构域和一个胞外区域,包含一个富含cys的结构域和2个纤维连接蛋白iii型重复序列。根据其胞外结构域序列的相似性和结合ephrin-A和ephrin-B配体的亲和力,ephrin受体可分为两类该基因在一些人类肿瘤细胞系中表达,并与肿瘤发生有关。[由RefSeq提供,2008年7月]This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]
EPHA1突变与药物:

常见问题
  • 如何在体龙基因完成所需的检测项目 流程简述 :在线咨询 - 采样送检 - 付款检测 - 检测分析 - 报告结果
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