基因名称：EPHA4 （EPH receptor A4）
别名： EK8,SEK,HEK8,TYRO1
基因ID：2043
Chromosome(GRCh37) ：2 Start: 222282747 End: 222437010 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因属于酪氨酸蛋白激酶家族的肾上腺素受体亚家族。eph和eph相关受体参与了发育事件的调节，特别是在神经系统中。eph亚家族的受体通常有一个单一的激酶结构域和一个胞外区域，包含一个富含cys的结构域和2个纤维连接蛋白iii型重复序列。根据其胞外结构域序列的相似性和结合ephrin-a和ephrin-b配体的亲和力，ephrin受体可分为两类。已发现该基因编码不同亚型的多个转录变体。[由RefSeq提供，2015年1月]This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
EPHA4突变与药物：
