EPHA5靶向药基因

基因名称：EPHA5  （EPH receptor A5）

别名： EK7,CEK7,EHK1,HEK7,EHK-1,TYRO4
基因ID：2044
Chromosome(GRCh37) ：4　Start:　66185281　End:　66536529　Strand:
信号通路： 细胞增殖
靶向药：
化疗药：

简介：该基因属于酪氨酸蛋白激酶家族的肾上腺素受体亚家族。eph和eph相关受体参与了发育事件的调节，特别是在神经系统中。eph亚家族的受体通常有一个单一的激酶结构域和一个胞外区域，包含一个富含cys的结构域和2个纤维连接蛋白iii型重复序列。根据其胞外结构域序列的相似性和结合ephrin-a和ephrin-b配体的亲和力，ephrin受体可分为两类。另外，还描述了编码不同亚型的剪接转录变体。[由RefSeq提供，2013年8月]This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]
EPHA5突变与药物：