基因名称：FAT2 （FAT atypical cadherin 2）
别名： CDHF8,CDHR9,HFAT2,MEGF1,SCA45
基因ID：2196
Chromosome(GRCh37) ：5 Start: 150883653 End: 150948505 Strand:
信号通路：
靶向药：
化疗药：
简介：该基因是果蝇脂肪基因的第二个人类同源基因，它编码一种在果蝇发育过程中控制细胞增殖所必需的肿瘤抑制因子。该基因产物是钙粘蛋白超家族的一员，是一组完整的膜蛋白，具有钙粘蛋白型重复序列。该基因产物除含有34个钙黏蛋白串联重复序列外，还含有两个表皮生长因子（EGF）样重复序列和一个层粘连蛋白G结构域这种蛋白很可能是一种细胞粘附分子，控制细胞增殖，在小脑发育中起重要作用[由RefSeq提供，2008年7月]This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]
FAT2突变与药物：
