基因名称：FOS （Fos proto-oncogene, AP-1 transcription factor subunit）
别名： AP-1,C-FOS,p55
基因ID：2353
Chromosome(GRCh37) ：14 Start: 75745477 End: 75748933 Strand: 1
信号通路：
靶向药： 厄贝沙坦
化疗药：
简介：fos基因家族由4个成员组成：fos、fosb、fosl1和fosl2。这些基因编码亮氨酸拉链蛋白，可与Jun家族的蛋白质二聚，从而形成转录因子复合物AP-1。因此，fos蛋白被认为是细胞增殖、分化和转化的调节因子。在某些情况下，fos基因的表达也与凋亡细胞死亡有关。The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
FOS突变与药物：
OVEREXPRESSION
药物：
厄贝沙坦
疾病：
结肠癌
TRUNCATING FUSION
药物：
Ziv-阿柏西普
疾病：
“骨上皮样血管瘤”
