基因名称：FOXO1 （forkhead box O1）
别名： FKH1,FKHR,FOXO1A
基因ID：2308
Chromosome(GRCh37) ：13 Start: 41129804 End: 41240734 Strand: -1
信号通路：
靶向药： Bromodomain Inhibitor
化疗药：
简介：该基因属于转录因子的叉头家族，具有独特的叉头结构域。该基因的特异功能尚未确定，但可能在肌源性生长和分化中发挥作用。该基因与pax3的易位与肺泡横纹肌肉瘤有关。This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.
FOXO1突变与药物：
PAX3-FOXO1
药物：
Bromodomain Inhibitor 疾病：
“肺泡横纹肌肉瘤”
PAX7-FOXO1 fusion
药物：
Ziv-阿柏西普
疾病：
“肺泡横纹肌肉瘤”
